【摘要】 目的:观察雷替曲噻联合羟基喜树碱和顺铂治疗晚期结直肠癌的安全性,探索治疗晚期结直肠癌的有效方法。方法:雷替曲噻3mg.m-2静滴15min,第1天;羟基喜树碱6mg.m-2,静滴第1～5天;顺铂10mg.m-2静滴第1～5天。每3周重复。结果:在6例复治患者中,5例至少进行了2个周期化疗,可评价疗效,其中,部分缓解(PR)1例,微效(MR)1例,稳定(SD)3例。与研究方案相关的毒副反应为:I～Ⅲ度恶心/呕吐3例,腹泻1例,Ⅲ度便秘1例;I度血总胆红素升高和谷丙转氨酶升高各1例;此外还有周围神经毒性1例,表现为早搏的心脏毒性1例。有1例女性患者出现Ⅲ度血小板下降,经治疗后恢复。未见Ⅳ级毒副反应,无治疗相关死亡。结论:雷替曲噻联合羟基喜树碱和顺铂治疗晚期结直肠癌安全性好,值得进一步观察疗效。更多还原

【Abstract】 Objective:To observe the safety of raltitrexed combined with cisplatin and hydroxycamptothecine in the treatment of advanced colorectal cancer.Methods:Six patients with advaned colorectal cancer who received previous regimens containg 5-FU,oxaliplatin or irinotican were treated with raltitrexed 3 mg·m-2 by intravenous infusion(iv)on day 1,combined with hydroxycamptothecine 6 mg·m-2 iv on day 1 to day 5,and cisplatin 10 mg·m-2(iv)on day 1 to day 5 every 21 days.Results:Frequent reported toxicity was nausea(grade 1-2),vomiting(grade 1-2),constipation(1 case with grade 3)and diarrhea(grade 1),other toxicities were thrombocytopenia and liver function impairment(all grade 1).All patients recovered after intensified supportive care.No treatment related death occurred.Conclusion:Raltitrexed combined with cisplatin and hydroxycamptothecine is safe in the treatment of advanced colorectal cancer.This protocol warrants further observation in terms of its efficacy.更多还原