【摘要】 目的:探讨肺癌患者血清中血管内皮生长因子(VEGF)的表达在肺癌患者诊治中的临床意义以及全血血小板和白细胞计数与血清VEGF水平间的关系。方法:采用酶联免疫(ELISA)方法检测未经任何治疗的肿瘤患者血清VEGF浓度,同时常规检测患者全血血小板和白细胞含量。采用线性回归分析血清VEGF浓度与全血血小板和白细胞含量的相关性。采用Kaplan-Meier方法比较不同血清VEGF含量者的生存情况。结果:肺癌患者血清VEGF浓度(1251.6±427.4)ng/L显著高于正常对照组(343.8±171.3)ng/L(P<0.01)。不同临床分期患者血清VEGF含量差异有统计学意义。相关分析表明,肺癌患者血清VEGF含量与血小板(r=0.523,P<0.01)和白细胞计数(r=0.511,P<0.01)呈正相关。血清VEGF高含量患者生存时间明显短于血清VEGF低含量者。结论:血清VEGF与肺癌临床分期进展密切相关,血清VEGF含量可作为判断肺癌预后评价的可靠参考指标。肺癌细胞分泌VEGF进入血液循环,从而促进肺癌的生长及转移,血清VEGF有可能作为肿瘤辅助诊断的指标。更多还原

【Abstract】 Objective:To investigate the clinical value of serum level of vascular endothelial growth factor(VEGF)in patients with lung carcinoma and to explore the mechanism of VEGF affecting lung carcinoma growth,development and prognosis.Methods:The serum level of VEGF was measured by enzyme-linked immunosorbent assay.The correlation between serum VEGF levels and blood cell counts was assessed by linear regression analysis.The relationship between the survival time and the serum level of VEGF was analyzed by the Kaplan-Meier method.Results:The serum level of VEGF was significantly higher in patients with lung cancer(1251.6±427.4 ng/L)than that in control group(343.8±171.3 ng/L).There was significant difference in serum level of VEGF between patients with different clinical stage.There was positive correlation between the serum level of VEGF and platelet counts(r=0.523,P<0.01).Serum VEGF levels also correlated with leukocyte counts(r=0.511,P<0.01).Survival analysis showed that the high serum VEGF was associated with a high risk of death.Conclusion:The serum VEGF may be an assisting diagnostic marker for lung cancer.VEGF plays an important role in lung carcinoma development.The serum level of VEGF may be a reliable predictor for prognosis.VEGF is secreted by tumor cells and subsequently released into blood.It may be the mechanism of VEGF to promote tumor growth and metastasis.更多还原