【摘要】 目的:探讨乙型肝炎病毒在孕妇早期妊娠绒毛细胞中的感染状态。方法:50例自愿行人工流产术的早期妊娠妇女,根据血清HBV表面标志物检测结果分为两组:实验组(乙型肝炎病毒携带组)20例和对照组(乙型肝炎感染标志均阴性组)30例。采用免疫组织化学链霉亲和素-生物素过氧化物酶复合物(SABC)法检测两组孕妇的绒毛细胞血清HBsAg、HBcAg;荧光定量PCR法检测HBV-DNA拷贝数。结果:实验组HBV-DNA阳性16例,阴性4例。HBsAg和HBcAg均阳性5例,HBsAg和HBeAg均阳性4例;对照组HBV-DNA均阴性,HBsAg和HBcAg均阴性。结论:乙型肝炎病毒可感染早期妊娠绒毛细胞。更多还原

【Abstract】 Objective:To study the presence of hepatitis B virus in early pregnancy villi cells in pregnant women.Methods:fifty early pregnant women of induced abortion of unconstraint were divided into two group according to examined hepatitis B virus serum markers: experiment group:early pregnant women with HBV and comparing group:early pregnant women without HBV.Immunohistochemical streptavidin-biotin peroxidase complex(SABC)staining with HbsAg,HBcAg and FQPCR staining with HBV-DNA in villi were used to examine the patients.Results:In the experiment group there were 16 positive cases of HBV-DNA and 4 negative cases of HB-DNA,and there were 5 positive cases of HBsAg and HBcAg,and there were 4 positive cases of HBsAg and HBeAg.HBV-DNA and HBsAg and HBcAg were not discovered in 30 villi of comparison group pregnant women.Conclusion:HBV may infect villous cells in early pregnancy.更多还原