【摘要】 目的:评价0.1%和0.03%他克莫司软膏联合308nm准分子激光治疗对紫外线治疗抵抗的白癜风皮损的疗效与安全性。方法:采用随机、自身对照的临床试验,每例患者选取紫外线治疗抵抗区域的皮损,随机选取躯体一侧皮损为治疗侧,采用他克莫司软膏联合308nm准分子激光治疗;另一侧为对照侧,仅用308nm准分子激光治疗。2个月后进行疗效判定。结果:联合治疗组有效率为89.0%,对照组为71.6%,两组间疗效比较差异有统计学意义(P<0.05)。结论:他克莫司软膏联合308nm准分子激光治疗白癜风起效快,疗效好。更多还原

【Abstract】 Objective: To evaluate the efficacy and safety of combination therapy of tacrolimus and 308 nm excimer laser in the treatment of vitiligo. Methods: A randomized self-controlled study was performed in 100 patients with vitiligo. The target lesions were all UV-resistant. Then we chose one side receiving the treatment of tacrolimus ointment plus the 308 nm excimer laser, and the other side only excimer laser monotherapy in each patient. Results: The total effective rate was 89.0% in the test group, and 71.6% in the control group, there was significant difference (P < 0.05) between the two groups. Conclusion: The combination treatment of tacrolimus ointment plus the 308 nm excimer laser is superior to 308 nm excimer laser monotherapy for the treatment of UV-resistant vitiliginous lesions.更多还原