【摘要】 为了探讨FAP-1在胃癌中的表达与细胞增殖和凋亡的关系及其临床意义,采用免疫组化SP法检测40例胃癌、20例胃良性肿瘤及10例正常胃粘膜组织中:FAP-1蛋白的表达水平。结果表明FAP-1蛋白的阳性表达主要定位在细胞浆内,少数也可见于核周。FAP-1蛋白在正常胃粘膜组织中呈阴性表达,胃良性肿瘤中的表达率为20%(4/20),胃癌中的阳性表达率70%(28/40),与前两者相比差异有显著性(P<0.01),而对照组与胃良性肿瘤组无显著性差异(P>0.05)。FAP-1的表达与胃癌的病理分化相关,而与年龄、性别、肿块大小、转移性无明显相关性。更多还原

【Abstract】 To investigate the roles of Fas-associated phosphatase-1(FAP-1) in the pathogenesis of gastric cancer,immunohistochemical SP method was employed to detect the expression of FAP-1 in 40 cases of gastric carcinoma and 20 cases of gastric adenoma and the normal controls(10 cases).In addition,their clinical pathological data were analyzed.The results show that There is no FAP-1 expression in normal intestinal tissues and low positive expression rate in benign cancer,but high positive expression rates are found in gastric carcinoma specimens(P<0.01),and there is no significant difference between the preceding two groups.Moreover,the expression of FAP-1 is markedly associated with tumor pathological grade(P <0.05),but not related to some clinicopathological characteristics such as the age 、sex 、size and metastasis.FAP-1 is widely owerexpressed in gastric carcinoma and its expression is associated with Ducks stage and pathological grade.FAP-1 may play an important role in the etiology and development of gastric carcinoma.更多还原