【摘要】 目的探讨人感染高致病性H₅N₁亚型禽流感的临床特征及防治手段。方法对确诊的一例人感染高致病性H₅N₁亚型禽流感的临床资料进行回顾性分析。结果患者为16岁男性,发病前无明确病、死禽接触史,发病后,病变由右下肺片状影迅速蔓延至双肺,且并发纵隔、皮下气肿,发病第5天出现急性呼吸窘迫综合征（ARDS）,治疗上采用以机械通气为主的综合治疗措施。发病第6天,中国疾病预防控制中心对患者咽试子标本采用逆转录一聚合酶链反应（RT-PCR）、实时荧光定量PCR（Real-time PCR）方法检测,提示A/HS/N1病毒核酸呈阳性并分离出禽流感（H₅N₁）病毒。从发病至死亡约10 d。结论人感染高致病性亚型H₅N₁禽流感是一种致命的传染病,如病变广泛,出现ARDS,预后不佳。更多还原

【Abstract】 Objective To study the clinical features and prevention means of the infection caused by the highly dathogenic avian influenza A（H₅N₁）.Method The clinical data which were confirmed to be an H₅N₁ infected case were analyzed retrospectively.Results The patient,16-year-old male,had no unambi guous history of direct contact with diseased or dead poultry before the onset of the disease.After the onset of the disease,chest X-ray showed flake shadow of the right lower lung quickly spread to the whole lung,associated with mediastinum,subcutaneous emphysema,acute respiratory distress syndrome（ARDS）was occurred on the fifth day.Mechanical ventilation is the primary measure in the comprehensive treatment.On the sixth day,Chinese Center for Disease Control and Prevention detected the pharyngeal specimen of the patient by RT - PCR,Real- time PCR method and suggested positive for the A/H5/N1 virus nucleic acid andis01ated the avian flu（H₅N₁） virus.The disease course was 10 days from onset of illness to death.Conclusions Human infection by the highly pathogenic avian influenza A（H₅N₁）is a deadly infectious disease.If the lesions is widespread and associated with ARDS,prognosis is poor.更多还原