【摘要】 目的探讨我国青年女性乳腺癌的临床和病理特点。方法全面收集国内关于青年女性乳腺的临床研究论文。青年女性(≤35岁)乳腺癌患者为研究组,>35岁以上女性乳腺癌患者为对照组。结果共检索符合纳入标准及排除标准的论文8篇,包括4881例病例,研究组发病至就诊时间明显长于对照组。采用随机效应模型进行meta分析,两组的TNM分期、腋窝淋巴结转移、免疫组化有显著差异,病理分型、5年生存率无明显差异。结论青年女性乳腺癌虽然更多发生腋窝淋巴结转移,TNM分期较晚,ER阳性率低,但经积极治疗,可能取得与中老年女性乳腺癌一样的效果,年龄不是影响预后的独立因素。更多还原

【Abstract】 Objective:To explore the clinic-pathological characteristics in young patients with breast cancer of our country.Methods: A systematic review of all relevant clinical studies on young women with breast cancer.Study group:young women with breast cancer(≤35 years),Control group:Mid-old women with breast cancer(>35 years).Results:Eight clinical studies including 4881 patients were identified.Delayed medical consultation was more often seen in study group than that of control group.Meta-analysis was done with random effects model.There were a significant difference in TNM,metastasis of lymph nodes and conditions of estrogen receptors(ER) between the two groups.There were no statistically significant differences in pathological typing,5-year survival rates between the two groups.Conclutions:Breast cancer of young women had more metastasis of lymph nodes,less positive rate of ER,later stage of TNM than that of Mid-old women with breast cancer,but prompt measure were taken,efficiency similar to mid-old patients with breast cancer would be obtainted.The age is not an independent factor of affecting prognosis.更多还原