【摘要】 缺血预处理是指心肌反复多次短暂缺血/再灌注,对随后长时间心肌缺血/再灌注的一种保护.缺血预处理对心肌的保护机制十分复杂,一般公认为线粒体ATP敏感性钾通道(mitoKATP)是心肌缺血预处理保护机制的终末效应器之一.mitoKATP开放后可通过以下3条途径对抗心肌缺血损伤:减少线粒体膜Ca2+通道对Ca2+内流的驱动力,抑制Ca2+内流,减轻心肌细胞钙超载;保护线粒体呼吸链,减轻自由基释放引起的损伤;抑制线粒体转换孔开放,防止细胞色素C从线粒体释放,减少细胞凋亡.更多还原

【Abstract】 Ischemic preconditioning refers to a mechanism whereby brief periods of ischemia-reperfusion render a tissue relatively resistant to the harmful effects of a subsequent prolonged period of ischemia.More and more studies are shown that mitochondrial ATP sensitive potassium channel plays an import role,acting as an end-effector,in these pathways.Activation of mitochondrial ATP sensitive potassium channel will reduce calcium influx through the mitochondrial calcium channel,then alleviate calcium overload;it can protect the mitochondrial respiratory chain,reduce free radical induced injury;it also inhibits the opening of mitochondrial permeability transition pore,decreases the cytochrome C released from mitochondria,and reduces apoptosis in ischemia hearts.更多还原