【摘要】 目的探讨白芍总苷对膝骨性关节炎(OA)患者血清一氧化氮(NO)和白细胞介素-1β(IL-1β)水平的影响。方法60例膝OA患者随机分成两组,分别给予白芍总苷和对乙酰氨基酚治疗组(A组)、单纯对乙酰氨基酚治疗组(B组)。测量患者在用药前及用药4周后血清的NO、IL-1β水平。结果用药4周后,两组NO和IL-1β的水平都有所下降,但白芍总苷治疗组NO和IL-1β下降较明显(P<0.05),有统计学意义。结论白芍总苷能有效辅助改善膝OA患者的临床表现,降低NO和IL-1β的水平。更多还原

【Abstract】 Objective To explore the effect of total glucosides of paeonia(TGP) on the serum levels of NO and IL-1β in patients with knee osteoarthritis(OA).Methods Sixty cases of osteoarthritis were divided into two groups randomly.Group A was given TGP combined acetaminophen,group B was given acetaminophen.Four weeks later,the levels of NO and IL-1β in serum were detected.Results The NO and IL-1β levels of TGP-treated patients were obviously lower than that of patients with acetaminophen.Conclusion TGP can decrease the serum NO and IL-1β levels,and improve symptoms of OA patients.更多还原