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近红外光谱测定复方对乙酰氨基酚片的有效成分

Determinations of the effective components in compound paracetamol based on near infrared spectroscopy

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【作者】 蒋雪陈泽琴郭嘉伟谢洪平

【Author】 JIANG Xue1,CHEN Ze-qin2,GUO Jia-Wei1,XIE Hong-ping1*(1.College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China;2.College of Chemistry and Chemical Engineering,China West Normal University,Nangchong 637000,China)

【机构】 苏州大学药学院西华师范大学化学化工学院苏州大学药学院 江苏苏州215123四川南充637000江苏苏州215123

【Abstract】 Based on the near infrared diffuse reflectance spectroscopy,the analytical methods of the fast and simultaneous determinations for asipilin,paracetamol and caffeine contained in the compound paracetamol have been built by the partial least squares method.For the three drug components asipilin,paracetamol and caffeine,the correlation coefficients 0.9994,0.9903 and 0.9994 have been obtained,the root mean square errors(RMSE) of the calibration samples were 0.313,0.520 and 0.0301,and the RMSE-s of the prediction samples were 1.07,0.464 and 0.309,respectively.

【基金】 化学生物传感与计量学国家重点实验室开放基金(2003-16)资助项目;苏州大学优秀中青年学术带头人基金(R2317043)资助项目
  • 【文献出处】 化学研究与应用 ,Chemical Research and Application , 编辑部邮箱 ,2007年11期
  • 【分类号】O657.33
  • 【被引频次】4
  • 【下载频次】324
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