【摘要】 分别对那格列奈B,H和S三种晶型的溶解度、溶解热进行了测定和计算.结果表明:那格列奈的S晶型与临床使用的H晶型溶解度均明显大于B晶型.B,H和S三种晶型的溶解热分别为42.84,28.44和29.14kJ·mol-1.此外,我们还新发现了不同于B,H,S晶型的X2晶型,并且制备出了无定型的那格列奈.更多还原

【Abstract】 The solubility values of three forms of nateglinide have been measured at different temperatures,and their enthalpies have been calculated. The results indicated that the solubility values of both S-form and H-form are large than that of B-form clearly. Moreover,a new X2-form of nateglinide was found and its amorphous form was prepared.更多还原