【摘要】 肼基二硫代甲酸甲酯与相应的醛或酮在微波辐射下经2~3.5 min反应,得到3-二取代甲(乙)撑肼基二硫代甲酸甲酯,产率91%~96%。再与胺在微波辐射下经35~45 min反应,得到目标化合物,产率80%~90%。合成的6个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析,对其结构进行确证,并测试了化合物的抑菌活性。更多还原

【Abstract】 Six thiosemicarbazones were synthesized.Under microwave irradiation,methyl hydrazinecarbodithioate was reacted with ketone or aldehyde in i-PrOH to form intermediate compounds(3-disubstituted methyl hydrazinecarbodithioate) with 91%～96% yield respectively(in 2～3.5 min).Intermediate compounds were reacted with N4-substituted piperazine and morpholine in ethanol to form thiosemicarbazones with 80%～90% yield(in 35～45 min).The structures of these compounds have been confirmed by means of their IR,1HNMR,and mass spectra.The antibacterial activities of the compounds have been tested against three kinds of bacteria.The results showed that the compounds possess different inhibitive effects.更多还原