【摘要】 【目的】观察氯胺酮超前镇痛对甲状腺次全切除手术患者术后疼痛的影响。【方法】选择择期行甲状腺次全切除患者40例,随机分成两组,K、C组,K组患者切皮前3 min静脉注射氯胺酮1.0 mg/kg及术中持续静脉注射0.5 mg/(kg.h)至术毕;C组切皮前及术中给予相同容量生理盐水。记录术后视觉模拟评分(VAS)及观察药物不良反应。【结果】K组术后VAS疼痛评分显著性低于C组(P<0.05);两组不良反应发生率的差异无显著性(P>0.05)。【结论】氯胺酮经静脉行超前镇痛用于甲状腺次全切除手术患者,效果确切,不良反应发生率低。更多还原

【Abstract】 【Objective】 To observe the effects of preemptive analgesia with intravenous Ketamine on the postoperative pain for patients undergoing subtotal thyroidectomy.【Methods】 Forty cases scheduled for selective surgery of subtotal thyroidectomy were randomly divided into two groups.In Group K,Ketamine 1.0 mg/kg was given intravenously 3 minutes before skin incision and thereafter 0.5 mg/(kg·h) infusion continuously until skin closure.Normal saline was used instead of Ketamine in Group C.Postoperative pain was assessed by VAS(visual analogue scale)-score at 4,8,12,24 hours after operation,while adverse effects were assessed. 【Results】The VAS-score of Group K was significantly lower than that of group C(P<0.05),but adverse effects such as nausea,vomit and swirl of two groups have no significant difference(P>0.05).【Conclusion】 Preemptive analgesia with intravenous Ketamine provides satisfactory relief of postoperative pain with no obvious side effects for patients undergoing subtotal thyroidectomy.更多还原