【摘要】 以青霉素G钾盐为原料,采用15%左右低浓度过氧乙酸为氧化剂合成青霉素G亚砜,反应时间2～2.5h,n(过氧乙酸):n(青霉素G钾盐)=(1.1～1.2):1.0,反应温度和结晶温度在0～5℃,总收率可达96%以上。所得青霉素G亚砜可直接从溶液中结晶析出,解决了产物与反应体系的分离。产品纯度较高。更多还原

【Abstract】 Penicillin G potassium salt is oxidized with 15% low concentration of peroxyacetic acid to synthesize penicillin G sulfoxide.The optimal conditions were as follows:reaction time 2.0～2.5 h,mole ratio of peroxyacetic acid and penicillin G K =(1.1～1.2):1.0,reaction and crystal temperature 0～5℃.The total yield of product was over 96%.The product could be crystallized directly from the solution and thus the separating problem was resolved.The purity of the product was high.更多还原