【摘要】 目的:研究几种常用促渗剂对美洛昔康体外经皮渗透的影响,改善美洛昔康体外经皮.方法:用紫外分光光度法检测浓度,采用改进Franz扩散池,比较几种常用促渗剂对美洛昔康渗透速率的影响.结果:氮酮(Azone)单独使用不能明显提高美洛昔康的渗透速率(P>0.05),而丙二醇.薄荷醇、丙二醇+Azone(1:1),丙二醇+薄荷醇(1:1)能显著提高美洛昔康的渗透速率(P<0.01).结论:丙二醇、薄荷醇、丙二醇+Azone(1:1)、丙二醇+薄荷肆(1:1)可作为促渗剂用于美洛昔康经皮吸收制剂.更多还原

【Abstract】 Objective:To study the effects of several penetration enhancers on the permeation of Meloxicam through skin in vitro and improve it.Methods:UV-Spectrophotometry and improved Franz diffusion cell were used to compare the influence of several penetration enhancers on the permeability of Meloxicam.Results:Exclusive use of Azone had little en- hancement effect on the permeability of Melxicam(P>0.05).Propylene glycol,menthol,Azone/propylene glycol(1:1.men- thol/propylene glycol(1:1)showed marked enhancement effects on the permeability of Meloxicam(P<0.01). Conclusion:propylene glycol,menthol,Azone/propylene glycol(1:1),menthol/propylene glycol(1:1)were found to be the proper penetration enhancers in the transdermal preparations of Meloxicam.更多还原