【摘要】 三磷酸肌醇(IP3)浓度的连续变化和线粒体活性调制出频率各异的钙振荡,以波的形式在胞质空间传播,然后被钙振荡频率敏感性分子接收,转化为对酶活性的调节,最终完成对物质代谢和基因表达的调控。运动性心脏重塑过程中的钙振荡频率可能比病理性心脏高。探索心肌细胞钙信号的分子解码器将是我们今后研究运动性心肌重塑可以努力的一个方向。更多还原

【Abstract】 Consecutive changes in intracellular IP3 concentration and mitochondrial activity modulated multiple frequencies of calcium oscillations,which spread as a form of wave in cytosol space and accepted by frequency-sensitive molecules.Calcium signal was transformed into regulations on enzyme activity,which ultimately regulated metabolism and gene expression.Maybe the frequency of calcium oscillation in exercise-induced cardiac restructure was much higher than that in pathological cardiac hypertrophy.Molecular decoder of calcium signals in cardiac myocyte will be one of the fuhure research topics on the exercise-induced cardiac restructure.更多还原