【摘要】 目的观察急性发作期以及缓解期的老年慢性阻塞性肺疾病(COPD)患者中IL-4、INF-γ与IL-18细胞因子水平表达变化。方法选择老年慢性支气管炎患者23例,采用竞争放射免疫法与双抗体夹心酶联免疫吸附法检测IL-4、INF-γ与IL-18水平变化,并进行急性发作期IL-4、INF-γ和IL-18水平与白细胞计数、分类的相关性分析。结果在COPD患者急性发作期的IL-4、INF-γ与IL-18水平均显著高于缓解期,而在缓解期仍然维持高水平状态,但三者与患者急性发作期白细胞中淋巴细胞、粒细胞计数、分类的无明显相关性。结论IL-4、IL-18与INF-γ参与COPD的气道炎症,而与白细胞数量变化无显著相关,提示COPD患者细胞因子网络调控有其特殊性。更多还原

【Abstract】 Objective To observe the changs of the surem levels of IL-4,INF-γ and IL-18 in elderly patients with COPD.Methods Twenty three elderly patients with COPD and 15 healthy controls were enrolled in the clinical research.Levels of IL-4,INF-γ and IL-18 were detected by RIA and ELISA.Then the relationship between IL-4,INF-γ,IL-18 and differential white blood cell count was analyzed by statistic methods.Results The levels of IL-4、INF-γ and IL-18 were significantly higher at acute stage than in catabasis for elderly patiens with COPD;higer levels of them were still kept in catabosis.There were no significant correlations between the surem level of IL-18,INF-γ,IL-4 and differential white blood cell count at acute stage.Conclusion IL-4,INF-γ and IL-18 play important roles in the airway inflammation of elderly patients with COPD,and have no correlation with changes of differential white blood cell count,which suggests that there is a specific cytokines regurlation system in elderly patients with COPD.更多还原