【摘要】 目的:探讨广西乙型肝炎病毒感染与原发性肝癌的关系。方法:采用回顾性研究方法对500例原发性肝癌病人与同期收治的500例非肿瘤病人的乙型肝炎病毒感染血清标志物检测结果进行对比分析。结果:病例组中有378例感染乙型肝炎病毒,感染率为75.6%,对照组有56例感染乙型肝炎病毒,感染率为11.2%,差异有统计学意义(P<0.0001)。单因素Logis-tic回归分析结果显示,乙肝家族史、HBsAg、HBsAb、HBeAg、HBeAb、HBcAb、小三阳、大三阳的OR值分别是7.511、24.566、0.077、9.747、2.997、10.375、5.263、25.184。而多因素Logistic回归分析结果显示HBsAg、HBcAb、乙肝家族史、大三阳的OR值分别是6.086、2.119、3.683、2.147。结论:乙型肝炎病毒感染在原发性肝癌病因学中起着十分重要的作用,HBsAg阳性、HBcAb阳性、乙肝家族史、大三阳是原发性肝癌的危险因素。更多还原

【Abstract】 Objective:To explore the relationship between the hepatitis B virus infection and the primary hepatocellular carcinoma(PHC)in Guangxi,China.Methods:We adopted the method of retrospection and carried out analysis by comparing the markers of Hepatitis B virus testing of the 500 cases of PHC and 500 controls.Result:The positive rates of HBV infection between in cases and controls showed significant difference(P<0.001),much higher in cases(75.6%)than those in controls(11.2%).The history of HBV, the positive of HBsAg,HBsAb, HBeAg, HBeAb, HBcAb were analyzed by single-factors logistic regression。The analysis of multiple-factors logistic regression showed the positive of HBsAg, HbcAb and the history of HBV with OR of 6.086,2.119,3.683 respectively. The positive of HbsAg , HbeAg and HBcAb with OR of 2.147.Conclusion:HBV infection could play extremely important role in PHC’s etiology.The positive of HBsAg,the history of HBV and positive with HBsAg,HBeAg,HBcAb are the PHC’S high-risk.更多还原