【摘要】 目的:探讨老年人非小细胞肺癌(NSCLC)放疗前后细胞免疫功能变化及其与疗效的关系。方法:将172例老年人NSCLC患者随机分为观察组(三维适形放疗,3DCRT)和对照组(常规分割放疗)各86例,比较两组患者的放疗效果和放疗前与放疗开始后7d,15d,30d,45d的T细胞亚群及自然杀伤细胞(NK)水平变化。结果:1观察组CR占45.3%,PR占51.2%,总有效率达96.5%;对照组CR占36.1%,PR占48.8%,总有效率为84.9%,两组总有效率比较差异有统计学意义(χ2=6.8910,P<0.01)。2两组患者T细胞亚群和NK水平放疗前与放疗开始后7d,15d,30d,45d比较,差异均有统计学意义(均P<0.05~0.001);观察组和对照组放疗开始后7d,15d,30d,45d T细胞亚群和NK水平比较,差异均有统计学意义(均P<0.05~0.001)。结论:放射治疗对老年人NSCLC患者的细胞免疫有一定的负面影响,但3DCRT的负面影响比常规分割放疗明显减轻(P<0.05);患者的细胞免疫水平越高,其疗效越好。更多还原

【Abstract】 Objective:To study the change of cellular immune function in elderly patients with non-small-cell lung carcinoma(NSCLC) before and after undergoing radiotherapy.Methods:172 cases with NSCLC were randomly divided into 3DCRT group and conventional radiotherapy group.The curative effect of two groups and the levels of the peripheral blood T cell subgroups and NK before and after radiotherapy 7d,15d,30d,45d were compared.Results:①The difference of curative rate between the two groups was significant statistically(χ2=6.8910,P=0.0086).②The levels of the peripheral blood T cell subgroups and NK before and after radiotherapy 7d,15d,30d,45d of two groups,showed the significant difference statistically(P<0.05～0.001);The levels of T cell subgroup and NK in 3DCRT group was higher than that in the control group.There was significant difference statistically between the two groups(P<0.05～0.001).Conclusion: Cellluar immune function was reduced after radiotherapy.But the immune function repression role of 3DCRT is milder than that of conventional radiotherapy.更多还原