【摘要】 目的对比观察熊去氧胆酸与易善复治疗非酒精性脂肪性肝炎(NASH)的疗效。方法将52例确诊为NASH患者随机分为治疗组(n=26)与对照组(n=26),治疗组口服熊去氧胆酸15~20mg/kg,每日3次。对照组口服易善复2粒,每日3次。疗程均为半年。结果治疗组治愈4例,好转20例,未愈2例,总有效率为92.3%;对照组治愈0例,好转23例,未愈2例,总有效率88.5%。两组疗效比较差异无统计学意义(Hc=1.166,P>0.05)。两组治疗后的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酸转肽酶(GGT)、甘油三酯(TG)、胆固醇(CHOL)、C-反应蛋白(CRP)水平均比治疗前明显下降(P<0.01),且治疗组的TG、CHOL改善程度优于对照组(P<0.01)。结论熊去氧胆酸与易善复对治疗NASH均有效,但熊去氧胆酸的降TG、CHOL作用更为明显,且其费用低,有较好的经济成本效益,值得临床应用。更多还原

【Abstract】 Objective To observe the effect of ursodeoxycholic acid(UDCA) and Essentiale Forte N on the treatment of non-alcoholic steatohepatitis.Methods 52 patients with non-alcoholic steatohepatitis were randomly divided into the treated group(n=26,treated with UDCA 15～20mg/kg,three times a day) and the control group(n=26,treated with Essentiale Forte N,two capsules,three times a day).The therapeutic course lasted 6 months.Results The effective rates were 92.3% in the treated group and 88.5% in the control group,no significant difference between the two groups(Hc=1.166,P>0.05).After the treatment,both groups significantly decreased the plasma levels of ALT,AST,GGT,TG,CHOL and CRP(P<0.01),among which the TG and CHOL levels decreased more in the treated group than in the control group(P<0.01).Conclusion UDCA and Essentiale Forte N both might effect on treating non-alcoholic steatohepatitis,while UDCA might be better than Essentiale Forte N in decreasing TG and CHOL levels and in the economic cost.更多还原