【摘要】 目的了解血管内皮生长因子(vascular endothelial growth factor,VEGF)在上皮性卵巢肿瘤中的表达及其意义。方法应用ELISA法检测上皮性卵巢癌患者(恶性组,n=30)、卵巢良性肿瘤患者(良性组,n=30)和正常妇女(对照组,n=20)外周血中VEGF水平。结果恶性组血清VEGF水平明显高于良性组和对照组(P<0.01),良性组和对照组相比较差异无统计学意义(P>0.05)。恶性组术前血清VEGF水平明显高于术后(P<0.01),良性组术前、术后的VEGF水平差异无统计学意义(P>0.05)。恶性组Ⅲ、Ⅳ期患者的VEGF水平高于Ⅰ、Ⅱ期,低分化G3期的VEGF水平高于高中分化G1、2期,差异有统计学意义(P<0.01)。结论检测血清VEGF水平对上皮性卵巢肿瘤的诊断及恶性上皮性肿瘤的分期、分级和预后有重要意义。更多还原

【Abstract】 Objective To investigate the expression and significance of vascular endothelial growth factor(VEGF) in human epithelial ovarian neoplasm.Methods Serum VEGF level was measured by enzyme linked immunosorbent assay(ELISA) in 30 ovarian carcinomas,30 benign ovarian tumors and 20 healthy women.Results Serum VEGF level was significantly higher in malignant group than that in benign and control groups(P <0.01),but there was no statistical difference between benign and control groups(P>0.05).VEGF expression was associated with the pathological grade and clinical stage(P<0.01),and reduced remarkably after operation(P<0.01).Conclusion Serum VEGF level is helpful in diagnosis,clinicopathologic grading and prognostic judgment of epithelial ovarian carcinoma.更多还原