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人类线粒体DNA异质性研究进展及在法医学中的应用
Research progress of human mitochondrial DNA heteroplasmy and its application in forensic medicine
【摘要】 线粒体DNA(mtDNA)异质性的存在使其在法医学应用变得复杂。本文对mtDNA异质性形成的可能原因、异质性的分布和遗传特点、异质性的筛查和定量方法、异质性对法医学的影响以及异质性的研究和展望等方面进行综述,探讨异质性在法医学上的应用价值。
【Abstract】 The existence of mtDNA heteroplasmy made it complicated to explain the analysis results of mtDNA of forensic biological samples.The article reviewed the possible formation mechanism,distribution and genetic characters,as well as the detecting and quantifying methods of mtDNA heteroplsmy.The application value of mtDNA heteroplasmy in forensic medicine was also discussed.
【关键词】 法医物证学;
线粒体DNA(mtDNA);
异质性;
【Key words】 Forensic biological evidence; Mitochondrial DNA (mtDNA); Heteroplasmy;
【Key words】 Forensic biological evidence; Mitochondrial DNA (mtDNA); Heteroplasmy;
- 【文献出处】 中国法医学杂志 ,Chinese Journal of Forensic Medicine , 编辑部邮箱 ,2007年05期
- 【分类号】D919
- 【被引频次】8
- 【下载频次】388