【摘要】 目的探讨强直性脊柱炎(AS)与肿瘤坏死因子(TNF)-α基因启动子-308位点多态性的关联情况。方法检索已发表的有关AS和与TNF-α基因启动子-308位点多态性的文献进行Meta分析。结果8篇文献共纳入987例AS患者和922名正常对照,综合分析显示不能认为TNF-α启动了-308位点等位基因多态性与AS间存在关联,OR=0.86(0.53,1.38),P=0.53;东西方人群亚群分析结果显示不能认为东方人群TNF-α启动子-308位点等位基因多态性与AS间存在关联,OR=1.06(0.34,3.33),P=0.91;西方人群TNF-α启动子-308位点等位基因多态性可能与AS间存在关联,OR=0.75(0.59,0.96),p=0.02;在东西方人群不能认为TNF-α启动子-308位点GA+AA基因型与AS间存在相关关系.OR=0.90(0.52,1.55),P=0.69;TNF-α启动子-308位点等位基因多态性与AS无关联,独立于HLA-B27,OR=0.71(0.42,1.20),P=0.20;在中国人群,TNF-α启动子-308位点等位基因多态性与AS骶髂关节炎严重程度可能存在关联,OR=0.37(0.15,0.90),P=0.03。结论Meta分析显示西方人群TNF-α启动子-308位点等位基因多态性可能与AS间存在关联,中国人群TNF-α启动子-308位点等位基因多态性与AS间无关联,但与AS骶髂关节炎严重程度可能存在关联。更多还原

【Abstract】 Objective To explore the association between ankylosing spondylitis(AS)with the poly- morphism in -308 site of tumor necrosis factor(TNF)-αpromoter region. Methods The literature about AS and polymorphism in -308 site of TNF-αpromoter region were searched and the meta analysis as performed. Results Eight studies enrolled 987 AS patients and 922 controls in total. The analysis showed that the fre- quencies of alleles and the genotypes had no statistical difference between AS group and the control group [OR=0.86(0.53, 1.38), P=0.53; OR=0.90(0.52, 1.55), P=0.69]. But the frequencies of alleles of western origin had statistical difference between AS group and the control group [OR=0.75(0.59, 0.96), P=0.02]; The TNF-αgene promoter polymorphism may play a role in the severity of sacroiliitis[OR=0.37(0.15. 0.90), P=0.03]. Conclusion The meta-analysis reveales that the alleles of -308 site of TNF-αpromoter region may be associated with AS in western ethnical group and play a role in the severity of saeroiliitis.更多还原