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FK506致肝功能异常2例并文献复习

Fk506 caused 2 cases liver damage after kidney transplantation and review of literature

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【Author】 LI Jinqing1),MA Lulin2),ZHAO Lei2),ZHANG Shudong2),HOU Xiaofei2),WANG Guoliang2),LUO Kangping2).1)Department of Urology,the Second Affiliated Hospital of Qingdao University Medical College,Qingdao 266042,Shandong;2)Department of Urology,the Third Hospital of Peking University

【机构】青岛大学医学院第二附属医院泌尿外科；北京大学第三医院泌尿外科；北京大学第三医院泌尿外科青岛266042；

【摘要】目的探讨FK506的肝毒性。方法报告2例肾移植术后应用FK506后,出现转氨酶、胆红素升高。结果1例仅停药后肝功恢复;另1例经停药,保肝治疗后恢复。结论FK506可引起肝脏损害,致转氨酶、胆红素升高,临床应用中注意该项副作用。更多还原

【Abstract】 Objective To discuss the drug-induced liver damage by FK506.Methods Clinical data of 2 cases whose alanine aminotransferase(ALT),bilirubin(T-Bil) elevating with oral take FK506 after renal transplantation had been analysed.Results One patient’s hepatic function had returned normal after stopping FK506;the other had returned normal after stopping FK506 and giving liver-protective remedies.Conclusion FK506 may cause liver damage and liver function,so they should be monitored in renal recipients particularly.更多还原

【关键词】 FK506；肝毒性；药物副作用；
【Key words】 Tacrolimus； Hepatotocxicity； Adverse drug reactions；

【文献出处】临床医学 ,Clinical Medicine , 编辑部邮箱 ,2007年11期

【分类号】R595.3
【被引频次】5
【下载频次】122

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