【摘要】 目的优化吉西他滨聚氰基丙烯酸正丁酯(GCTB-PBCA-NP)纳米粒的制备工艺。方法以GCTB-PBCA-NP的粒径、包封率和载药量为指标,在单因素考察的基础上,通过正交设计优化处方和制备工艺。结果制备的GCTB-PBCA-NP平均粒径为(112±9)nm,包封率为(54.12±2.43)%,载药量为(11.08±0.89)%。结论制备的纳米给药系统为拓展吉西他滨的临床给药新剂型提供了参考。更多还原

【Abstract】 Objective To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles(GCTB-PBCA-NP).Methods According to the particle size,the entrapment efficiency and the loading quantity of GCTB-PBCA-NP,single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.Results The mean particle size of the NP was(112±9) nm with an entrapment efficiency of(54.12±2.43)% and drug loading of(11.08±0.89)%.Conclusion An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.更多还原