【摘要】 目的研究甲状腺肿与甲状腺癌DNA倍体差异的临床意义。方法采用流式细胞术对34例甲状腺肿(结节性甲状腺肿22例,弥漫性甲状腺肿12例)及29例甲状腺癌(分化型甲状腺癌20例、未分化型甲状腺癌9例)进行DNA倍体分析及细胞周期检测。结果甲状腺癌组(分化型、未分化型)DNA异倍体率明显高于甲状腺肿组(结节性、弥漫性)(P<0.05),甲状腺癌组(分化型、未分化型)DNA整倍体细胞S期百分率也明显高于甲状腺肿组(结节性、弥漫性)(P<0.05),未分化型与分化型甲状腺癌的DNA异倍体率之间无差异(P>0.05),未分化型与分化型甲状腺癌的DNA整倍体细胞S期百分率有差异(P<0.05)。结论DNA倍体分析及细胞周期检测有助于甲状腺癌的早期诊断。更多还原

【Abstract】 Objective Clinical significance of DNA ploid variability in goiter and thyroid cancer.Methods DNA ploid and cell cycle are analyzed by flow cytometry among 34 goiters(22 nodular goiters,12 diffuse goiters) and 29 thyroid cancers(20 differentiated thyroid cancers,9 undifferentiated thyroid cancers).Results DNA heteroploid percentage of thyroid cancer group(differentiated and undifferentiated thyroid cancers) is much highter than that of goiter group(nodular and diffuse goiters)(P<0.05),and the numbers of DNA euploid cells at stage S in thyroid cancer groupl differentiated and undifferentiated thyroid cancers is also much highter than that of goiter group(nodular and diffuse goiters)(P<0.05).There are no differences of DNA heteroploid percentage between undifferentiated and differentiated thyroid cancer group(P>0.05),and some differences of the numbers of DNA euploid cells at stage S between undifferentiated and differentiated thyroid cancer group(P<0.05)were observed.Conclusions DNA ploid and cell cycle would be availability to the early diagnosis of thyroid cancer.更多还原