【摘要】 目的:探讨E-选择素(E-selectin)+G98T,+A561C基因多态性与原发性高血压及左室重构的关系.方法:对105例原发性高血压患者(高血压组)及94健康正常人(对照组)进行E-selectin+G98T,+A561C基因多态性检测及超声心动图、血脂水平检测.结果:①E-selectin+A561C各基因型在原发性高血压组和对照组间的分布差异存在统计学意义(P<0.05);②E-selectin+G98T基因型在原发性高血压组和对照组间的分布差异无统计学意义(P>0.05);等位基因频率在两组中分布差异亦无统计学意义(P>0.05);③原发性高血压组内,AC-CC基因型更倾向于发生左室肥厚(P<0.05);④原发性高血压组和对照组E-selectin+G98T位点及+A561C位点各基因型组间血脂水平比较差异均无统计学意义(P>0.05).结论:E-selectin+A561C位点单核苷酸多态性与原发性高血压具有相关关系,C等位基因可能是原发性高血压发病的遗传易感基因.C等位基因原发性高血压患者更倾向于出现左室重构.更多还原

【Abstract】 AM:To study the relationship between E-selectin gene polymorphisms and left ventricle reconstitution in patients with essential hypertension.METHODS:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to determine +G98T and +A561C locus mutation polymorphisms in E-selectin gene in patients with essential hypertension and controls.Automated Biochemical Analyzer was used to measure the serum lipids.RESULTS:① There was significant difference in frequencies of genotype in E-selectin +A561C polymorphism between the essential hypertension group and the control group(P<0.05).② There was no significant difference in distribution of the E-selectin gene +G98T genotype between the essential hypertension group and the control group(P>0.05).③ In essential hypertension group,AC-CC genotype was prone to suffer the left ventricle reconstitution(P<0.05).④ There was no significant difference in the levels of serum lipids for different genotypes of +G98T or +A561C locus between the essential hypertension group and the control group.CONCLUSION:E-selectin gene +A561C polymorphism is associated with essential hypertension.C allele may be a risk factor for essential hypertension,and essential hypertension patients with C allelt are prone to suffer left ventricle reconstitution.更多还原