【摘要】 目的:研究聚乳酸-聚乙二醇嵌段共聚物6000(PLEG6000)对软膏剂中尼莫地平的促透效果。方法:以PLEG6000作为促透剂,制备不同载药量的尼莫地平软膏剂,并对其累积透过量、稳态透皮速率、透皮时滞及PLEG6000促透效果进行研究和分析。结果:相同促透剂条件下,尼莫地平软膏剂载药量在30～45mg/g时透皮效果较好;PLEG6000对尼莫地平软膏剂的促透作用比Azone略强。结论:实验结果表明,采用PLEG6000作为促透剂所制备的尼莫地平软膏剂具有良好的透皮效果。更多还原

【Abstract】 Objective:Nimodipine-loaded transdermal ointment was prepared,the transdermal enhancing effect d PLEG6000 was evaluated.Methods:Nimodipine-loaded ointment was prepared with PLEG6000 as permeation enhancer,the percutaneous parame- ters(Q,J and Tlgg)and the permeation enhancing effect of PLEG6000 was mensurated through rots skin.Results:The transdermal effect of nimndipine-loaded ointment was better when the loading amount was among 30～45 mg/g.The enhancing effect of PLEG 6000 to nimodipine-loaded ointment was slightly better than Azone.Conclusion:The transdermal ability of the prepared nimodip- ine-loaded ointment was favorable when using PLEG6000 as an effective permeation enhancer.更多还原