【摘要】 生长激素-胰岛素样生长因子(GH-IGF)轴对人体的生长发育起着重要的调控作用。对肢端肥大症病人的研究表明,GH-IGF轴对结直肠癌的发生和发展也起着重要的作用。重组人生长激素(rhGH)究竟能否应用于结直肠癌病人?阻断GH-IGF轴对结直肠癌病人是否有积极的治疗作用?这些都是目前广大学者关注的问题。现就GH-IGF轴与结直肠癌的关系作一综述。更多还原

【Abstract】 The growth hormone(GH)-insulin-like growth factor(IGF)-I axis is an important modulator of growth and development.In addition to the classical role as endocrine hormones,the components also regulate a wide range of biological functions through paracrine and autocrine mechanisms.Their potent mitogenic and anti-apoptotic effects play a critical role in the regulation of rapidly renewing epithelial cell populations such as those found in the colon.Recent epidemiological evidence from acromegaly patients suggests an association between inappropriate regulation of the GH-IGF-I axis and the development of colorectal cancer.However,the molecular mechanisms and signalling pathways responsible are only beginning to be unravelled,as are the relative contributions of the endocrine and autocrine or paracrine effects.更多还原