【摘要】 目的:探讨生长抑素受体(SSTR)5种亚型在胰腺癌组织中的表达及临床意义,为临床应用生长抑素(SS)及其类似物诊断、治疗胰腺癌提供依据。方法:采用免疫组化EnVision法检测50例胰腺癌及46例非癌胰腺组织中SSTR 1~5亚型的表达。结果:SSTR 1~5在胰腺癌组织中均有表达,除SSTR 1表达较低外,SSTR2~5均为高表达。SSTR 1~5表达阳性率分别为50%、94%、82%、90%和96%;SSTR 1~5在非癌胰腺组织中亦有类似表达,阳性率分别为28.3%、97.8%、67.4%、78.3%和97.8%。胰腺癌与非癌胰腺组织比较,除SSTR 1表达显著高于非癌胰腺组织外(P<0.05),SSTR 2~5并无差异。结论:SSTR在胰腺癌及非癌胰腺组织均有表达,但SSTR 1在胰腺癌表达阳性率显著高于非癌胰腺组织。更多还原

【Abstract】 Objective: To explore the expression of SSTR 1,SSTR 2,SSTR 3,SSTR 4 and SSTR 5 in human pancreatic cancer and non-cancer pancreatic tissue.Methods: Immunohistochemical staining of 5 SSTR subtypes was performed by the EnVision technique for paraffin sections of 50 cases pancreatic cancer and 46 cases non-cancer pancreatic tissue. Results: Positive staining for all 5 SSTR subtypes was observed in pancreatic cancer and non-cancer pancreatic tissues.The expression of SSTR 1 was significantly higher than non-cancer pancreatic tissues.No significant difference of SSTR 2～5 expression was found in pancreatic cancer tissues and non-cancer pancreatic tissues.Conclusion: The expressions of SSTR 1～5 are detected in human pancreatic cancer and non-cancer pancreatic tissues.The expression of SSTR 1 is obviously higher than that of SSTR2～4.更多还原