【摘要】 目的总结神经内镜辅助经眶上锁孔入路显微手术切除大、巨型垂体腺瘤的经验及体会。方法对我院2001年2月～2006年10月收治的lO例大、巨型垂体腺瘤患者行神经内镜辅助经眶上锁孔入路显微手术切除术。结果肿瘤全切除3例,次全切除4例,大部切除3例。术后无死亡,无严重的手术并发症。术后随访6个月～5年,原有症状均有所改善。9例视力受损病人中改善8例。6例激素水平异常增高病人中降至正常4例。2例次全切除的患者术后接受γ刀治疗,大部切除3例中1例再次经鼻蝶窦内镜手术全切除了肿瘤,另一例行普通放疗控制症状。所有病例随访期间均未发现有明显复发迹象。结论神经内镜辅助经眶上锁孔入路显微手术切除大、巨型垂体腺瘤损伤小、疗效满意。更多还原

【Abstract】 Objective To report our experience of using neuroendoscope-assisted transsupraorbital keyhole approach to remove large and giant pituitary adenomas.Methods Ten patients admitted to our hospital between Feb.2001 and Oct.2006 were performed on by neuroendoscope-assisted microsurgery via the supraorbital keyhole approach to remove their large and giant pituitary adenomas.Results Total tumor resection was achieved in 3 cases,subtotal in another 4 cases and partial in the remaining 3 cases.No postoperative death or severe complications.During the follow-up study ranged from 6 months to 5 years,the original symptoms were all relatively ameliorated: visual impairment was ameliorated in 8 out of 9 cases;among the 6 patients with abnormally high level of hormone,4 recovered to normal level;2 patients underwentγ-knife treatment after subtotal resection;1 out of the 3 patients undergone partial resection received endoscopic endonasal transsphenoidal surgery to totally remove the tumor and another one received conventional radiotherapy to control its symptoms. There was no obvious evidence of recurrence in our group during the follow-up.Conclusion Neuroendoscope-assisted microsurgery via the supraorbital keyhole approach is minimally invasive and efficacious for the resection of large and giant pituitary adenomas.更多还原