【摘要】 目的探讨白细胞介素-6(IL-6)对大鼠脑缺血的保护作用。方法将75只SD大鼠随机分为3组(n=25),采用线栓法制作大鼠脑缺血模型,手术一组:侧脑室注射IL-60.5μg,注射速度为15μg/h;手术二组:鼠尾静脉注射IL-6 0.5μg,注射速度为15μg/h;对照组:侧脑室注射等体积生理盐水。术后对大鼠进行神经症状评分及测量各组大鼠脑梗塞范围。结果70只大鼠进入结果分析。分析指标:(1)脑梗塞范围:手术一组和手术二组较对照组明显减小(P<0.01),分别减少(24±3)%和(22±3.5)%,提示神经功能缺损明显减轻。(2)神经症状评分:手术一组和手术二组较对照组明显降低(P<0.01),提示神经功能障碍明显减轻。结论IL-6对大鼠脑缺血有明显的神经保护作用。更多还原

【Abstract】 Objective To study the protective effect of interleukin-6(IL-6)on rats with cerebral ischemia.Methods Middle cerebral artery occlusion(MCAO)was achieved by inserting nylon surgical thread in 75 SD rats.The rats were then divided into 3 groups(n=25/group):group A were injected 0.5μg IL-6 into lateral cerebral ventricle(15μg/h);group B were injected 0.5μg IL-6 into caudal vein(15μg/h);control group were injected 4υL saline into lateral cerebral ventricle(15μg/h). Nervous symptom scores and the dimension of cerebral ischemia were measured after operation. Results Cerebral infarct size was decreased by(24±3)% and(22±3.5)% in group A and B respectively as compared with control group(P<0.01),which indicated that neurological deficiency was relieved in group A and B.Neurological scores were also lower in group A and B than those in control group(P<0.01),showing the attenuation of the neurological deficiency in group A and B.Conclusion IL-6 has a protective effect on nervous system in rats with cerebral ischemia.更多还原