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去甲氧柔红霉素为主的联合化疗治疗急性白血病
Analysis of the effect of idarubicin-containing regimen in the treatment of acute leukemia
【摘要】 目的分析去甲氧柔红霉素(IDA)和柔红霉素(DNR)治疗急性白血病(AL)的疗效和毒副作用。方法 59例 AL 患者,初治43例,复发难治16例。急性非淋巴细胞白血病(ANLL)39例,用IA 方案化疗;急性淋巴细胞白血病(ALL)18例,用 IDA 联合长春新碱、异环磷酰胺、泼尼松方案化疗;急性混合细胞白血病(MAL)2例,用 IDA 联合长春新碱、环磷酰胺、阿糖胞苷方案化疗。同期48例患者采用 DNR 为主的方案治疗。结果 IDA 为主方案的完全缓解(CR)43例,部分缓解(PR)4例,总有效率79.7%;初治43例中,CR34例,PR3例,总有效率86.1%;复发难治16例中,CR9例,PR 1例,总有效率62.5%;39例 ANLL 中,CR 28例,PR 3例,总有效率79.5%;18例 ALL 中,CR 15例,PR 1例,总有效率88.9%;DNR 为主方案的总有效率为80.4%。结论 IDA 是疗效确切、安全、可靠的抗白血病药物。
【Abstract】 Objective To evaluate the efficacy and toxicity profiles of idarubicin(IDA)-containing reg- imens in the treatment of acute leukemia(AL).Methods A group of 59 AL patients were treated with IDA- containing regimens:39 with acute myelogenous leukemia(AML),18 with acute lymphoblastic leukemia(ALL) and two with acute mixed cell leukemia(MAL).During the same period,a group of 48 AL patients were treat- ed with daunorubicin(DNR)-containing regimens.Results In the IDA-eontaining regimens treated group,43 patients achieved a complete remission(CR),with a 72.9 % CR rate,4 patients partial remission(PR),with a 6.8% PR rate.In the DNR-containing regimen treated group,the CR rate was 80.4 %.Conclusion IDA- based regimens are effective and safe.It favorably influences the cuteome of AL patients.
- 【文献出处】 白血病.淋巴瘤 ,Journal of Leukemia & Lymphoma , 编辑部邮箱 ,2007年06期
- 【分类号】R733.71
- 【被引频次】1
- 【下载频次】14