【摘要】 探讨2型糖尿病男性患者六项性激素水平与骨密度（BMD）的关系。应用RIA检测49例男性2型糖尿病患者和46例男性非糖尿病患者血清促卵泡生成激素（FSH）、促黄体生成激素（LH）、垂体泌乳素（PRL）、雌二醇（E₂）、孕酮（P）和睾酮（T）的水平;用双能X线吸收法测定患者桡骨远端BMD,并按其BMD值分为骨质疏松（OP）组、骨量减少（L）组和骨量正常（N）组。结果显示,2型糖尿病组中BMD明显低于非糖尿病组,有显著差异（P<0.05）;在糖尿病组OP患者FSH、LH、PRL水平升高,E₂、T、P水平降低,与非糖尿病组OP者比较有显著性差异（P<0.05或P<0.01）;与BMD相关因素进行直线回归分析显示:OP患者BMD与FSH、LH、PRL水平呈显著负相关,与T、E₂、P水平呈正相关。作者认为男性2型糖尿病患者伴有骨量丢失与垂体-性腺轴功能失衡有关,性腺激素缺乏更容易患骨质疏松。更多还原

【Abstract】 To explore the relationship between serum sex hormone level and bone mineral density （BMD）in male patients with type 2 diabetes,the serum levels of sex hormone（FSH,LH, PRL,E₂,P and T） were measured by RIA in 49 male patients with type 2 diabetes and 46 male subjects without diabetes.The BMD of all patients in distal radius were measured by dual-ener- gy x-ray absorption method.The patients were divided into 3 groups according to the value of BMD:osteoporosis group （OP）,loss bone mass group （L）,normal bone mass group （N）. The results showed that the BMD in patients with type 2 diabetes were markedly lower than that in patients without diabetes（P<0.05）.The serum levels of FSH,LH and PRL in OP group with type 2 diabetes were significantly higher than those in OP group without diabetes（P<0.05）.The serum E₂,T and P levels in OP group with type 2 diabetes were markedly lower than those in OP group without diabetes（P<0.01）.The serum levels of FSH,LH and PRL were remarkably negatively correlated with BMD.The serum T,E₂ and P were positively cor- related with BMD.The results suggested that the loss of bone mass in patients with type 2 dia- betes is relative to the disturbance of pituitary gonad axis.The patient who lacks gonad hor- mones was susceptible to osteoporosis.更多还原