【摘要】 目的:观察益气活血汤治疗不稳定型心绞痛(UAP)气虚血瘀证的临床疗效,及对血栓形成前状态(PTS)部分敏感分子标志物水平的影响。方法:选择不稳定型心绞痛气虚血瘀证患者41例,随机分为治疗组和对照组,两组均常规给予抗血小板、抗凝、调脂、抗心绞痛及对症治疗,治疗组加用益气活血汤,分早晚2次口服,每日1剂。两组均分别观察心绞痛、心电图及中医证候疗效,同时观察治疗前后一氧化氮(NO)、内皮素(ET)、血管性假性血友病因子(vWF)、血浆组织型纤溶酶原激活物(t-PA)、纤溶酶原激活物抑制物(PAI-Ⅰ)及纤维蛋白原(FG)等指标变化。结果:治疗组中医证候疗效、心绞痛疗效均明显优于对照组(P<0.05);治疗组在降低ET、FG、vWF、PAI-Ⅰ,提高NO、t-PA方面较对照组明显(P<0.05,或P<0.01)。结论:益气活血汤可有效防治不稳定型心绞痛,其机制可能与其对血栓形成前状态凝血和纤溶系统部分敏感分子标志物的影响有关。更多还原

【Abstract】 Objective: To observe the clinical effects of Yiqi Huoxue Decoction(YQHXD),a traditional Chinese prescription for supplementing Qi and activating blood circulation,in treating unstable angina pectoris(UAP) complicated with syndrome of Qi-deficiency and blood-stasis(SQDBS),and observe its effects on some sensitive molecular markers in prethrombotic state.Methods: Forty-one patients with UAP and SQDBS were chosen and divided into treatment group and control group at random.Patients in both groups were conventionally treated with therapeutic methods such as antiplatelet,anticoagulation,lipid-modulating,antiangina and symptomatic treatments.Simultaneously,patients in treatment group took YQHXD,twice daily,one dose per day.The effects of YQHXD on angina pectoris,syndromes in traditional Chinese medicine and electrocardiogram as well as the changes of fibrinogen(FG),nitric oxide(NO),endothelin(ET),von Willebrand′s factor(vWF),plasminogen activator inhibitor(PAI-Ⅰ) were observed and compared in both groups.Results: The therapeutic effects of YQHXD on syndromes in traditional Chinese medicine and angina pectoris in treatment group were better than those of control group(P<0.05).Compared with those of control group,the levels of FG,ET,vWF and PAI-Ⅰ increased significantly,and the levels of t-PA and NO decreased significantly(P<0.05,P<0.01).Conclusion: YQHXD can effectively treat UAP,and the mechanism might be related with its effects on some sensitive markers of coagulation and fibrinolysis system in prethrombotic state.更多还原