【摘要】 目的研究乳腺单纯黏液腺癌的临床病理特征,比较它和浸润性导管癌的区别,并分析病理特征和预后的关系。方法回顾性分析了23例可手术乳腺单纯性黏液腺癌患者和同期863例对照的浸润性导管癌的临床病理资料。结果单纯性导管癌占全部同期乳腺癌的2.6%以下,患者中位年龄51岁(23岁~86岁),肿块中位大小2.5 cm;单纯性黏液腺癌患者中位年龄62岁(36~83岁),肿块中位大小3.0 cm。浸润性导管癌和单纯性黏液腺癌之间的患者年龄、肿块大小、腋淋巴结状态转移数、ER状态和HER-2状态存在显著的差异,后者的临床病理特征明显优于前者。而且ER+PR+组和ER+PR-组在单纯性黏液腺癌中的比例显著提高。中位随访17.6月(1~24个月)内,无一例单纯性黏液腺癌发生复发转移。对照的863例浸润性导管癌患者中,2例死亡,6例复发转移。结论单纯性黏液腺癌临床病理学特征显著优于浸润性导管癌,提示了其预后的优势,而且ER阳性比例高,年龄大,内分泌治疗可能更加行之有效。更多还原

【Abstract】 Aim To study the clinical and pathological characteristics of pure mucinous carcinoma of the breast,and to analyze the association between it and prognosis by comparing the pure mucinous cancer with invasive ductal carcinoma.Methods 23 cases of operable pure mucinous carcinoma of the breast patients were analyzed retrospectively and 863 controlled records of invasive ductal carcinoma patients during the same duration were also analyzed.Results The proportion of pure mucinous cancer of breast in all the breast cancer is less than 2.6%.Pure mucinous cancer patients were older than all patients(median age 62 y versus 51 y) and the median tumor size is larger too(3.0 cm vs.2.5 cm).The differences of age,tumor size,axliary lymph nodes status,ER and HER-2 statuses between pure macinous and invasive ductal carcinoma were obvious.It also showed that the proportion of ER+PR+ and ER+PR-subgroups were higher in the pure mucinous group than that in invasive ductal carcinoma patients.In the median follow-up time of 17.6 months,no case relapsed or died in 23 mucious patients while 2 patients died and 4 patients recurred or metastasized in 863 invasive ductal carcinoma patients.Conclusions Pure mucinous carcinoma of the breast has better clinical and pathologic characteristics than invasive ductal breast cancer,which indicates its advantage in prognosis and survival.Moreover,the patients of pure mucinous breast cancer are always ER+ and elderly.Adjuvant endocrine therapy may be more effective to them.更多还原