【摘要】 目的回顾性调查住院溃疡性结肠炎(UC)患者,探讨近7年住院病例UC的临床特征及内镜检出情况。方法调查安徽省六安市三家医院2000~2006年期间住院UC120例患者的临床特点、治疗、逐年住院情况和同期内镜检出率。结果120例UC中,男∶女为1.61∶1,发病高峰年龄在30~39岁,平均年龄为(42.5±14.4)岁,且男女之间有差异。病情以轻度(42.5%)和中度(30.8%)为主。临床类型以初发型(65.8%)及慢性复发型(26.7%)为主。主要症状有腹泻(98.35%),血便(95.8%),腹痛(89.2%)等。肠外表现(2.5%)和并发症(3.3%)少见。病变部位以左半结肠为主(69.2%)。治疗以氨基水杨酸类(68.3%)和类固醇激素(31.7%)为主。单纯内科治疗总有效率达97.5%,死亡1例(0.8%)。结论UC近年有逐年增加的趋势,以轻中度为主,肠外表现及并发症少。内科治疗以氨基水杨酸类及类固醇激素为主,疗效良好,但院外病人依从性差,易复发。更多还原

【Abstract】 Aim To analyze the clinical characters of hospitalized patients with ulcerative colitis and the corresponding colonoscopy detection rate.Methods The data of 120 cases of UC were obtained from three hospitals in Lu’an city of Anhui province from 2000 to 2006.The clinical characters,treatment,hospitalization and the corresponding colonoscopy detection rate were reviewed.Results Of 120 patients,74 men,36 women,the ratio of male/female is 1.61∶1,and the mean age is 42.5±14.4 years.There is significant difference between male and female.The peak years of invasive age are from 30 to 39 years.Most of the hospitalized UC patients revealed mild(42.5%) or moderate severity(30.8%).In all cases,65.8% were first onset,and 26.7% were chronic relapsing.The major symptoms were diarrhea(98.35%),bloody stool(95.8%) and abdominal pain(89.2%).About 2.5% of UC patients had extraintestinal manifestations,and 3.3% had complications.Among UC patients,69.2% was colitis of left-colon.The mainstay for UC treatment was 5-aminosalicylate(68.3%) and glucocorticoids(31.7%),and the therapeutic effect was good.The remission rate by medicine reached 97.5%.The mortality was 0.8%(1 case).Conclusions There has been an increasing number of hospitalized UC in recent years,mostly with mild to moderate severity.There is few case of UC with extraintestinal manifestations and complications.The treatment with SASP/5-ASA or steroids for patients has acquired excellent therapeutic effect.However,the compliance of patients out of hospital is not so well.Therefore,the relapse rate was high among those patients.更多还原