【摘要】 目的:建立高效液相色谱法测定卡莫氟片含量及溶出度。方法:采用的色谱柱为 Bondapak C₁₈不锈钢柱（5μm,250 mm×4.6mm）。流动相为:甲醇-水（90:10）,流速:1mL·min^-1,检测波长为258 nm。结果:卡莫氟进样浓度在5～50μg·mL^-1范围内线性关系良好,r=0.9998。平均回收率为99.86%～100.1%（n=3）。结论:该法简便、准确、专属,可用于该片的质量控制。更多还原

【Abstract】 Objective:To estalish a method for determination of content and dissolution of carmofur tablets by HPLC.Method:It employed a Bondapak C₁₈ column（5μm,250mm×4.6mm） and a mobile phase of methanol- water（90:10） and detected at 258nm.The flow rate was 1.0mL·min^-1.Results:Within the range of 5-50μg ·mL^-1,carmofur presented a good linear relationship between amount and peak area（r=0.9998,n=5）.The av- erage recoveries were 99.86%-100.1%（n=3）.Conclusion:The method is specific,accurate and convenient, and can be used for quality control of the carmofur tablets.更多还原