节点文献
高效液相色谱法测定卡莫氟片含量及溶出度
HPLC determination of content and dissolution of carmofur tablets
【摘要】 目的:建立高效液相色谱法测定卡莫氟片含量及溶出度。方法:采用的色谱柱为 Bondapak C18不锈钢柱(5μm,250 mm×4.6mm)。流动相为:甲醇-水(90:10),流速:1mL·min-1,检测波长为258 nm。结果:卡莫氟进样浓度在5~50μg·mL-1范围内线性关系良好,r=0.9998。平均回收率为99.86%~100.1%(n=3)。结论:该法简便、准确、专属,可用于该片的质量控制。
【Abstract】 Objective:To estalish a method for determination of content and dissolution of carmofur tablets by HPLC.Method:It employed a Bondapak C18 column(5μm,250mm×4.6mm) and a mobile phase of methanol- water(90:10) and detected at 258nm.The flow rate was 1.0mL·min-1.Results:Within the range of 5-50μg ·mL-1,carmofur presented a good linear relationship between amount and peak area(r=0.9998,n=5).The av- erage recoveries were 99.86%-100.1%(n=3).Conclusion:The method is specific,accurate and convenient, and can be used for quality control of the carmofur tablets.
- 【文献出处】 药物分析杂志 ,Chinese Journal of Pharmaceutical Analysis , 编辑部邮箱 ,2006年08期
- 【分类号】R927
- 【被引频次】2
- 【下载频次】62