【摘要】 目的研究阿托伐他汀对急性脑梗死患者血清 C 反应蛋白(CRP)的影响,并分析其临床意义。方法对2003年4月至2005年8月东风汽车公司茅箭医院内科收治的62例经 CT 或 MRI 确诊的急性脑梗死患者,随机分为两组,两组均给予常规治疗,治疗组在此基础上予阿托伐他汀20 mg,每晚1次口服,分别在确诊24 h 内和治疗2周时使用免疫比浊法测定两组患者 CRP 水平。结果治疗组治疗2周后血清 CRP 明显降低,与对照组比差异有统计学意义。结论阿托伐他汀可以显著降低急性脑梗死患者血清 CRP 水平,对脑梗死病情变化及预后具有一定意义。更多还原

【Abstract】 Objective It is to study the influence of atorvatatin on serum C-reactive protein(CRP)level in acute cer- ebral infarction patients and to analyze its clinical significance.Methods 62 patients with acute cerebral infarction di- agnosed by CT or MRI were chosen and divided into two groups randomly.Both the groups were treated with normal method and the treatment group was given atorvastatin 20mg per day.Serum CRP levels in the two groups were measured by immunnturbidimetry within24h after final diagnosis and at two weeks the level decreased obviously in treatment.Re- slllts Serum CRP levels all increased in the patients.After treatment for two weeks the level decreased obviously in treatment group.The difference was significant compared with control group.Conclusion Atorvastatin can markedly reduce the serum CRP level in acute cerebral infarction patients and has important significance for the pathogenetic condi- tion change and prognosis of cerebral infarction.更多还原