【摘要】 目的建立HPLC测定注射用萘普生钠的含量及有关物质的方法。方法用十八烷基键合硅胶为填充剂,乙腈-水-冰醋酸(体积比49:50:1)为流动相,检测波长为262 nm。结果萘普生钠在0.09～1.2 mg·mL-1质量浓度范围内线性关系良好,相关系数r=0.999 8。平均回收率为99.7%,精密度及稳定性均较好。结论本方法稳定,重现性好,结果准确,可同时用于测定含量及有关物质检查。更多还原

【Abstract】 Objective To establish methods for the determination of naproxen sodium for injection and its related substances. Methods The mobile phase consisted of acetonitrile-water-glacial acetic acid(49:50:1).Detection wavelength was set at 262 mn. Results There was good linear correlation in the range of0.09–1.20 mg·mL-1(r=0.999 8). The average recovery of naproxen sodium for injection was 99.7%(n=6).Conclusions The method is rapid, simple, and accurate.更多还原