【摘要】 目的　研究高血压合并睡眠呼吸暂停综合征 (SAS)病人呼吸道正压通气治疗与常规药物治疗对血压的影响。方法　根据多导睡眠呼吸监测和2 4h血压监测资料 ,入选 43例高血压合并SAS病人 ,随机分为常规组 (2 2例 )和呼吸道正压通气治疗组 (2 1例 ) ,均给予常规降压药物治疗 4周 ,在常规治疗基础上加用呼吸道正压通气治疗一夜 ,观察两组治疗前后 2 4h血压变化。结果　两组病人治疗后2 4h平均收缩压、舒张压、夜间舒张压均明显下降 (P <0 .0 5 ) ,但仍高于正常值 ,而夜间收缩压无明显变化。呼吸道正压通气治疗组治疗后 2 4h平均收缩压、舒张压进一步降低 ,夜间收缩压和夜间舒张压显著降低。结论　对高血压合并睡眠呼吸暂停综合征病人 ,在常规降压药物治疗基础上需应用呼吸道正压通气治疗。更多还原

【Abstract】 Objective To explore the influnce of CPAP on blood pressure in patients with hypertension and sleep apnea syndrome. Methods According to the data of 24-hour ABPM and polysomnography(PSG) ,patients with hypertension and sleep apnea syndrome were randomly divided into two groups. All patients had accepted antihypertensed therapy for 4 weeks. One group accept CPAP treatment at the base of routine therapy.We compared the data from 24-hour ambulatory blood pressure before and after therapy. Results 24-hour BP and nighttime BP were all decreased(P<0.05)after 4 weeks’ antihypertensed therapy in two groups.But still higher than normal CPAP treatment.In the group with 24-hour BP and nighttime BP was significantly decreased(P<0.01). Conclusion To most of patients with Hypertension and sleep apnea syndrome,CPAP treatment can effectively decrease 24-hour BP and nighttime BP.更多还原