【摘要】 目的　了解广州地区脑血管病病人感染产超广谱 β -内酰胺酶革兰阴性杆菌情况及对 18种抗生素耐药性进行调查分析。方法　对广州 12家医院分离的 3 499株革兰阴性杆菌 ,其中包括分离自神经内科、神经外科脑血管病病人 3 89株 ,检测其超广谱 β -内酰胺酶 ,并以K -B法检测所有菌对 18种抗生素的敏感性。结果　广州地区常见革兰阴性杆菌产超广谱 β -内酰胺酶总体检出率 3 8.4% (819/213 4) ;神经科脑血管病病人超广谱β -内酰胺酶检出率 5 5 .5 %(12 1/2 18) ;其中大肠埃希菌、肺炎克雷伯菌的检出率分别是 5 3 .1%、5 7.5 %。结论　广州地区脑血管病病人大肠埃希菌、肺炎克雷伯菌超广谱 β -内酰胺酶检出率与总体检出率比较有统计学意义 (P <0 .0 1) ,18种抗生素的耐药率所有产酶株与非产酶株比较有统计学意义。更多还原

【Abstract】 Objective To investigate the infection situation of extended-spectrum β-lactamases gram-negative bacilli in cerebrovascular patients in Guangzhou and their resistances to 18 antibiotics.Methods Detecting extended-spectrum β-lactamases in 3 499 strains of gram-negative bacilli isolated from 12 hospitals, including 389 strains from neurological department. And detecting resistances of 18 antibiotics with K-B method.Results The occurrence rate of extended-spectrum β- lactamases in gram-negative bacilli is 38.4%(819/2 134); the occurrence rate of extended-spectrum β-lactamases of cerebrovascular patients in neurological department is 55.5%(121/218),among which the occurrence rates of E.coli and K.pneumoniae are 53.1%,57.5% respectively.Conclusion The occurrence rates of E.coli and K.pneumoniae in Cerebrovascular Patients are obviously higher than the average(P<0.01),The 18 antibiotics resistance rate in β-lactamases producing strains is greatly higher than that in β-lactamases negative strains.更多还原