【摘要】 目的:研究姜黄素对动脉粥样硬化(AS)内皮细胞损伤的保护作用。方法:复制实验性大鼠AS模型,测定超氧化物歧化酶(SOD)活性和丙二醛(MDA)、前列环素(PG I2)、血栓素A2(TXA2)含量。采用免疫组化、RT-PCR方法检测AS斑块细胞间粘附分子-1(ICAM-1)和ICAM-1mRNA的表达水平。结果:姜黄素可使血清MDA及血浆TXB2(TXA2)含量降低,6-酮-前列腺素F1 a(PG I2)升高,并使AS斑块ICAM-1表达水平降低。结论:姜黄素抗AS作用的机制可能与其抗氧化、抗血栓及抗粘附作用等保护血管内皮细胞功能密切相关。更多还原

【Abstract】 Objective: To investigate the protective effect of total curcumin to the damage of atheromatous endothelial cell.Method: The experimental atheromatous model of SD rat was duplicated;the activity of maleic dialdehyde（MDA） and the content of superoxide dismutase（SOD）,prostacyclin（PGI₂） and thromboxane A₂（TXA₂） were assayed.Immunohistochemical method was adopted to measure the intercellular adhesion molecule 1（ICAM-1） in atheromatous plaque,and the expression of ICAM-1mRNA were detected by RT-PCR.Results: Curcumin can reduce blood serum MDA,the content of plasm TXA₂;raise the content of PGT2.The expression of ICAM-1 was reduced.Conclusion: The mechanism of curcumin anti-atherosclerosis probably due to the function of protecting angio-endothelial cell,anti-oxidation,anti-thrombus and anti-adhesiveness.更多还原