【摘要】 目的观察IUGR的胎盘病理改变及EGFR表达情况,探讨IUGR的发病机制。方法选取IUGR患者及正常妊娠妇女胎盘各18、25例,常规HE染色及EGFR免疫组化分析,观察胎盘形态学及EGFR表达情况。结果IUGR组绒毛间质纤维化及纤维素样坏死>3%,合体滋养细胞结节>30%,绒毛血管减少、闭塞的数量均明显高于对照组。IUGR者EGFR的表达比对照组高。结论IUGR的胎盘病理改变是造成IUGR胎盘功能减退的形态学基础。EGFR在胎儿胎盘的生长发育过程中及IUGR的病理过程中起重要作用。更多还原

【Abstract】 Objective:To observe the pathological change of placenta in IUGR and the expression of EGFR,explore the pathogenesis of IUGR.Methods:Placental samples were collected from 18 pregnancies of IUGR and from 25 normal pregnant woman.The tissue sections were assessed for morphological change with HE-stain section and analyzed by EGFR immunohistochemical technique.Results:The numbers of stroma fibrosis and fibrinoid necrosis of villi >3%,villous syncytial knots>30%,decreased and obstruction villous vascular were significantly higher in the group of IUGR than that of control group EGFR was higher in IUGR than in control group.Conclusion:The pathological changes of IUGR ard the morphological base that lead to the hypofunction of placenta EGFR has important effect on the infant growth and development and IUGR pathology process.更多还原