【摘要】 目的探讨乙型肝炎表面抗原(HBsAg)携带者孕妇及其新生儿应用乙肝免疫球蛋白(HBIG)对阻断乙肝母婴传播的效果。方法HBIG组(A组)66例,于孕28、32、36w分别注射HBIG 200IU,非HBIG组(B组)68例仅常规产前检查及监护。新生儿分为Ⅰ、Ⅱ、Ⅲ组,Ⅰ、Ⅱ组新生儿注射HBVac 10μg和HBIG 100 IU,Ⅲ组新生儿只注射HBVac 10μg。结果HBIG组较非HBIG组新生儿出生时外周血HBsAg阳性率显著降低,P<0.05。Ⅰ、Ⅱ、Ⅲ组婴儿6月龄HBsAb阳转率Ⅰ>Ⅱ>Ⅲ。结论对乙肝病毒携带孕妇孕晚期应用HBIG可以显著降低新生儿外周血HBsAg阳性率;HBsAg携带孕妇孕晚期应用HBIG,新生儿出生时应用HBIG和HBVac联合免疫,可以显著提高婴儿6月龄HBsAb。更多还原

【Abstract】 Objective:To explore the preventive effect of mathernofatal Hepatitis B virus(HBV) transmission after pregnant women carring HBsAg and their newborns have been passive immunized Hepatitis B immunoglobulin (HBIG).Methods:Groups A (n=66),which HBIG 200 IU was given monthly in late pregnancy;Group B (n=68),which abtained only common antenatal care.The newborns were also divided into three Groups :Group Ⅰand Group Ⅱ abtained both HBIG and HBVac,and Group Ⅲ abtained HBVac only.Results :The positive rate of HBsAg of newborns (age≤24h) in Group A was significantly lower than that in Group B.As the infants were 6 months old,the HBsAb positive rate of infants was Group Ⅰ> Group Ⅱ> Group Ⅲ.Conclusion:The pregnant women carring HBsAg given HBIG monthly during late pregnancy can effectively reduce the positive rate of HBsAg of newborns,The pregnant women given HBIG monthly during late pregnancy and offsprings abtained HBIG nad HBVac as well can effectively prove the positive rate of HBsAb of 6 moths infants.更多还原