【摘要】 目的探讨不育男性无精子症或严重少精子症与Y染色体微缺失之间的关系。方法利用9个Y染色体特异序列标签位点,以多重PCR法检测无精子症或严重少精子症患者的Y染色体微缺失情况。结果180例无精子症或严重少精子症患者中共检出Y染色体微缺失15例,缺失率为8.3%。精液正常者(对照组)20例未发现Y染色体微缺失。9例Y染色体微缺失的无精子症患者睾丸细胞学检查均未发现精子。结论Y染色体微缺失是造成男性精子发生障碍的常见病因之一。更多还原

【Abstract】 Objective:to assess the relationship between azoospermia or severe oligozoospermia and Y chromosomal microdeletions.Methods:Infertile men with azoopermia or severe oligozoospermia were screened by multi-polymerase chain reactions with 9 Y chromosome specific sequence-tagged site labels.Results:Microdeletions were detected in 8.3%(15/180) infertile men with azoospermia or severe oligozoospermia and in 0 of normospermic men.Among 9 azoospermic men with Y chromosome microdeletion,no sperm was found in testicular cell smears,Conclusion:Y chromosome microdeletion is one of the causes which result in male spermatogenetic obstacle.更多还原