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白细胞介素1B-511多态性与侵袭性牙周炎的关系

Association analysis between Interleukin-1B-511 polymorphism and aggressive periodontitis.

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【作者】 李启艳赵红珊孟焕新张立徐莉陈智滨

【Author】 LI Qi-yan1, ZHAO Hong-shan2, MENG Huan-xin1, ZHANG Li1, XU Li1, CHEN Zhi-bin1.(1. Department of Periodontology, School of Stomatology, Peking University, Beijing 100081 2.Department of Immunology and Peking University Center for Human Disease Genomics, Peking University Health Science Center, Peking University, Beijing 100083)

【机构】 北京大学口腔医学院牙周科北京大学医学部基础医学院免疫学系人类疾病基因研究中心北京大学口腔医学院牙周科 北京100081北京100083北京100081北京100081

【摘要】 目的研究中国人群中IL-1B-511位点单核苷酸多态性(singlenucleotidepolymorphism,SNP)与侵袭性牙周炎(aggressiveperiodontitis,AgP)之间的关系。方法提取122名AgP患者和95名健康对照者外周静脉血基因组DNA,应用聚合酶链反应-限制性片段长度多态性的方法,分析IL-1B-511位点SNP与AgP的关联性。结果男性AgP组杂合基因型的频率较男性健康对照组升高并有统计学意义(P=0·048);A2+基因型/等位基因A2与吸烟联合作用显著增加了AgP的易感性(基因型:P=0·022;等位基因:P=0·006)。结论IL-1B-511位点的SNP可能与中国人群中男性个体的AgP易感性有关;该位点的SNP与吸烟可能对AgP的易感性具有联合效应。

【Abstract】 Objectives:To study whether Interleukin-1B (IL-1B) -511 genotype and/or allele were associated with aggressive periodontitis (AgP) in Chinese.Methods: AgP group consisted of 122 patients and healthy controls group consisted of 95 subjects. Single nucleotide polymorphism at IL-1B -511 was analyzed by standard Polymerase Chain Reaction-Restriction Fragment Length Polymorphism assay. Results: The frequency of IL-1B -511 A1/A2 heterozygote was significantly increased in male AgP group compared to male control (P = 0.048). The adjusted OR of AgP for combined A2+ genotype and smoking was 12.45 (P = 0.022), and for combined allele 2 and smoking was 18.25 (P = 0.006).Conclusion: The IL-1B -511 polymorphism may play an important role in determining AgP susceptibility in Chinese male. A possible combined effect of the IL-1B -511 polymorphism and smoking on AgP susceptibility was suggested.

【基金】 国家自然科学基金(基金编号:#30271411);教育部教育振兴行动计划特殊专项(“九八五”工程)(基金编号:北京大学人类疾病基因研究中心2001-8);国家高科技项目(863计划)(基金编号:2002AA21701)
  • 【文献出处】 中国优生与遗传杂志 ,Chinese Journal of Birth Health & Heredity , 编辑部邮箱 ,2005年07期
  • 【分类号】R781.4
  • 【被引频次】9
  • 【下载频次】164
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