【摘要】 目的探讨导致围产儿出生缺陷的各种可能相关因素。方法采用以医院为基础的监测方法收集资料。调查对象为孕28周至产后7天在我院住院分娩的围产儿,包括活产、死胎和死产。结果共监测围产儿6518例,检出出生缺陷儿97例,出生缺陷发生率为14.88‰,其中占前三位的依次为先天性心脏病、多指(趾)和胎儿水肿综合征,其发生率分别为53.70/万、13.81/万、12.27/万。缺陷儿中有各种合并症者68例,占70.10%,存在可能致畸因素者32例,占32.99%。结论孕早期是预防先天性畸形形成的关键。出生缺陷与羊水过多过少、胎儿生长受限、双胎、不孕等高危妊娠密切相关。加强对高危妊娠的监护和产前诊断可早期发现缺陷儿。先天性心脏病发生率有上升趋势,目前已位居我院出生缺陷的首位,应加强对其诊断及预防措施的研究。更多还原

【Abstract】 Objective: To investigate the various possible factors related to birth defects. Methods: Data were collected with the method of hospital-based cluster sampling. During the data collection period, all live or still births with 28 weeks or more of gestation were assessed within seven days after delivery.Results: From among 6518 births, 97 defects were identified, with a prevalence rate of 14.88‰, and the most common defects in order of prevalence being congenital heart disease, polysyndactyly and fetal edama syndrome, with prevalence rates of 53.70, 13.81,and 12.27 per 10,000 respectively.Complication was found in 68 cases, accounting for 70.10%, and possible deforming factors existed with 32 defected newborns, accounting for 32.99%.Conclusion: Birth defects are closely related to high risk pregnancy, and the early period of pregnancy is a crucial time for the prevention of congenial defects. To enable early discovery of birth defects, monitoring of high risk pregnancy should be strengthened.Our data has indicated a predominant incidence of congenital heart disease, and thus calls for more intensive study of effective measures for the prevention and diagnosis of this defect.更多还原