【摘要】 目的探讨CT灌注成像在胶质瘤术前分级中的作用及价值。方法对25例胶质瘤患者(低级星形细胞瘤11例,高级星形细胞瘤14例)术前行CT灌注检查,分析CBF、CBV及PS图,测量肿瘤实质部分的CBF、CBV及PS的绝对值及相对值并进行统计学处理。结果胶质瘤的CBF值、CBV值及PS值均较正常脑组织升高,低级星形细胞瘤病变区的rCBF1.41±0.16,rCBV2.31±0.28,rPS6.67±2.88;高级星形细胞瘤病变区的rCBF4.96±2.17,rCBV4.69±1.98,rPS19.19±9.19。二者差异有明显统计学意义,CBV值P<0.05,CBF值及PS值P<0.01。肿瘤病变区CBF值、CBV值与PS值之间统计学处理均呈显著正相关,r值分别为0.822、0.753、0.657,P≤0.001。结论CT灌注成像对胶质瘤术前分级有临床实用价值。更多还原

【Abstract】 Objective To detect the role and value of CT perfusion imaging in preoperative grading gliomas. Methods Twenty-five glioma patients (11 low grade astrocytomas and 14 high grade astrocytomas) underwent CT cerebral perfusion examination before operation. The patients’ raw data were transferred to workstation and processed to analyze the CBF, CBV and PS maps. The absolute value and relative value of CBF, CBV and PS were measured in the parenchyma part of glioma and were processed statistically. Results The values of CBF, CBV and PS in glioma were all higher than those of the normal cerebral tissue. In the lesion area of low grade astrocytoma: rCBF 1.41±0.16,rCBV 2.31±0.28, rPS 6.67±2.88. In the lesion area of high grade astrocytoma: rCBF 4.96±2.17, rCBV 4.69±1.98, rPS 19.19±9.19. The significant differences of P value were noted as follows: CBV (P<0.05), CBF and PS (P<0.01). There were positive correlations among the CBV, CBF and PS value of tumor area, and the r value was 0.822, 0.753, and 0.657, respectively (P≤0.001). Conclusion CT perfusion imaging is valuable in preoperative grading gliomas in clinical procedures.更多还原