【摘要】 目的观察半乳凝素-3(Gal-3)在垂体泌乳素腺瘤中的表达情况。方法采用免疫组织化学方法,测定16例侵袭性垂体泌乳素腺瘤和16例非侵袭性垂体泌乳素腺瘤中Gal-3的表达水平。结果在侵袭性垂体泌乳素腺瘤和非侵袭性垂体泌乳素腺瘤中均有Gal-3的表达,其中侵袭性垂体泌乳素腺瘤中Gal-3的表达水平明显高于非侵袭性垂体泌乳素腺瘤(P<0.05雪。结论Gal-3增高可能与垂体泌乳素腺瘤的侵袭性有关。更多还原

【Abstract】 Objective To investigate the expression of galectin-3(Gal-3)in prolactinomas. Methods Expressions of Gal-3 were evaluated by immunohistochemistry using polyclonal antibody in 16 invasive prolactinomas and 16 prolactinomas. Results Gal-3 was expressed both in invasive prolactinomas and noninvasive prolactinomas while significantly higher expression seen in the invasive prolactinomas(P < 0.05). Conclusion Gal-3 expression may be used as a useful indicator to determine the invasiveness and prognosis of prolactinomas.更多还原